Acetic Acid → 4-{(1R)-2-[(6-{4-[3-(Cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol acetate

Participants

Reaction Steps

A stirred solution of (1R)-2-[(6-{4-[3-(Cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol (110 mg) in glacial AcOH (5 ml) and water (0.3 ml) was heated at 85° C. for 40 min. The solution was evaporated to dryness and the residue was purified by Biotage™ column chromatography on silica using DCM-EtOH-ammonia (50:8:1) as eluent. The residue was dissolved in MeOH, treated with glacial AcOH and the solvent was removed to give the title compound (76 mg). LCMS RT=2.6 min ES+ve 548

Provenance & Evidence