反应详情

Iodocyclopentane (3.93 ml) was added to a mixture of 3-bromobenzenethiol and potassium carbonate (5.4 g) in acetone (50 ml) and the reaction was stirred under nitrogen for 1.5 h. A further portion of iodocyclopentane (2 ml) was added and the mixture was stirred for 1 h. The solvent was evaporated and the residue was partitioned between water and EtOAc. he combined organic extracts were washed with NaOH (2N), brine and dried (Na2SO4). The resulting oil was purified using biotage™ chromatography on silica using cyclohexane as eluant to give the title compound (3.6 g). LCMS RT=4.1 min

1. stirringthe mixture was stirred for 1 h
2. customThe solvent was evaporated
3. customthe residue was partitioned between water and EtOAc
4. washwere washed with NaOH (2N), brine
5. dry with materialdried (Na2SO4)
6. customThe resulting oil was purified