HCID 69119338, compound → HCID 69119693, compound

HRID 2118354Notes

Reaction equation

HRID 2118354 reaction equation
[CH:1]1([S:6]([C:9]2[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][CH2:27][CH:28]([C:30]3[N:35]=[C:34]4[CH2:36][O:37]C(C5C=CC=CC=5)[O:39][C:33]4=[CH:32][CH:31]=3)[OH:29])[CH:12]=[CH:13][CH:14]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>O.C(O)(=O)C>[CH:1]1([S:6]([C:9]2[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][NH:26][CH2:27][CH:28]([C:30]3[N:35]=[C:34]([CH2:36][OH:37])[C:33]([OH:39])=[CH:32][CH:31]=3)[OH:29])[CH:12]=[CH:13][CH:14]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 69119338HCID 69119338, compound

Product 1

HCID 69119693HCID 69119693, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 2-[(6-{4-[3-(cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-(2-phenyl-4H-[1,3]dioxino[5,4-b]pyridin-6-yl)ethanol (61 mg) in water (5 ml) and glacial acetic acid (5 ml) was heated under reflux for 0.5 h. The reaction mixture was concentrated in vacuo to afford the title compound. LCMS RT=2.63 min 548(M+H)+

Workup

  1. temperatureunder reflux for 0.5 h
  2. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b312788d4e224623850bbdce33cfcce3
Source dataset
uspto-grants-2008_10
Patent number
US07442839B2

Reaction notes

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