HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → N-Benzyl-6-{4-[3-(cyclopentylsulfonyl)phenyl]butoxy}hexan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 1-{4-[(6-Bromohexyl)oxy]butyl}-3-(cyclopentylsulfonyl)benzene | HCID 69119827 | — |
| Product | N-Benzyl-6-{4-[3-(cyclopentylsulfonyl)phenyl]butoxy}hexan-1-amine | HCID 69119361 | — |
Reaction Steps
1-{4-[(6-Bromohexyl)oxy]butyl}-3-(cyclopentylsulfonyl)benzene (Example 11ii) (50 mg) was dissolved in benzylamine (0.5 ml), and heated in a microwave oven at 150° for 10 min. Excess benzylamine was removed in vacuo and the residue purified on a silica SPE bond elut cartridge, eluting with EtOAc-cyclohexane mixtures, to give the title compound, (40 mg) LCMS RT=2.74 min
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442839B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-5fe9a571801f402da25bbacd094d4e67 |
| Source note | uspto-grants-2008_10 |