Diethyl Ether → tert-butyl N-(2-methyl-1-oxopropan-2-yl)carbamate

HRID 2118468Notes

Reaction equation

HRID 2118468 reaction equation
[C:1]([NH:8][C:9]([CH3:14])([CH3:13])[C:10](O)=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[H-].CN1CCNCC1[Al+]C1CNCCN1C.CCOCC>O1CCCC1>[C:1]([NH:8][C:9]([CH3:14])([CH3:13])[CH:10]=[O:11])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 2733845N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanineHCID 18792082Bis(1-methylpiperazin-2-yl)alumanylium;hydride

Product 1

HCID 14578674tert-butyl N-(2-methyl-1-oxopropan-2-yl)carbamate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

N-Boc-2-aminoisobutyric acid is dissolved in tetrahydrofuran and is stirred at 0° C. under argon. Bis(N-methylpiperazinyl)aluminum hydride is added and the reaction mixture is heated to reflux overnight. Ether is then added, and the excess hydride is quenched with saturated NaCl. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl. The solution is dried with Na2SO4 and evaporated to yield N-Boc-2-amino-2-methylpropanal.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureto reflux overnight
  3. customthe excess hydride is quenched with saturated NaCl
  4. customThe aqueous phase is separated
  5. extractionextracted with ether
  6. washThe combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl
  7. dry with materialThe solution is dried with Na2SO4
  8. customevaporated

Sources & evidence

ORD record
ord-85fdbf4c7584420a90c9178b100cf244
Source dataset
uspto-grants-1987_07
Patent number
US04678675

Reaction notes

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