Sulfuric Acid → 1-Chloroisoquinoline-5-sulfonic acid

HRID 2118496Notes

Reaction equation

HRID 2118496 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[S:12](=O)(=[O:15])([OH:14])[OH:13]>>[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([S:12]([OH:15])(=[O:14])=[O:13])[C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 140539Isoquinoline, 1-chloro-

Product 1

HCID 137300201-Chloroisoquinoline-5-sulfonic acid

Procedure

1-chloroisoquinoline is dropwise added to 2 to 20, preferably 3 to 10, equivalent of forming sulfuric acid while cooling with ice to carry out a reaction at 10° to 120° C., preferably at 20° to 100° C., for 4 to 24 hours. The reaction solution is poured on ice water to obtain a crystal of 1-chloro-5-isoquinolinesulfonic acid.

Workup

  1. temperaturewhile cooling with ice
  2. customa reaction at 10° to 120° C.
  3. additionThe reaction solution is poured on ice water

Sources & evidence

ORD record
ord-027a2fc05b5d4020b46d3b8fb512521b
Source dataset
uspto-grants-1987_07
Patent number
US04678783

Reaction notes

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