Dibenzylhydroxylamine → HCID 14224089, compound

HRID 2118563Notes

Reaction equation

[CH2:1]([N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:17]1([N:30]2[C:34](=[O:35])[CH:33]=[CH:32][C:31]2=[O:36])[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[C:27](=[O:28])[CH:26]=[CH:25][C:24]1=[O:29]>>[CH2:10]([N:8]([O:9][CH:25]1[CH2:26][C:27](=[O:28])[N:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:30]2[C:34](=[O:35])[CH2:33][CH:32]([O:9][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:31]2=[O:36])[C:24]1=[O:29])[CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 69297Dibenzylhydroxylamine

HCID 83156N,N'-2-Phenylenedimaleimide

Product 1

HCID 14224089HCID 14224089, compoundYield 67.9%

Procedure

The procedure of Example 1 is repeated using 5.33 g (25 mmole) of N,N-dibenzylhydroxylamine and 3.35 g (12.5 mmole) of N,N'-ortho-phenylenedimaleimide. The residue is purified by preparative HPLC (Silica gel: 7:3 heptane:ethyl acetate eluent) to give 5.9 g (34%) of a white solid.

Workup

customThe residue is purified by preparative HPLC (Silica gel: 7:3 heptane:ethyl acetate eluent)

Sources & evidence

ORD record: ord-357d48fb6a3f4c5ca4bdbedddc3590bd
Source dataset: uspto-grants-1987_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04678826

Reaction notes

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