Potassium Carbonate → HCID 178477246, compound

HRID 2118637Notes

Reaction equation

HRID 2118637 reaction equation
Br.[C:2]([OH:10])(=O)[CH:3]([CH2:5][C:6]([OH:8])=[O:7])[OH:4].NC(=N)[SeH:13].C(=O)([O-])[O-].[K+].[K+].[Au:21](Cl)(Cl)Cl.[CH2:25]([P:27]([CH2:30][CH3:31])[CH2:28][CH3:29])[CH3:26]>C(O)C.C(Cl)Cl>[C:2]([O-:10])(=[Se:13])[CH:3]([CH2:5][C:6]([O-:8])=[O:7])[OH:4].[Au+3:21].[CH2:25]([P:27]([CH2:30][CH3:31])[CH2:28][CH3:29])[CH3:26].[C:2]([O-:10])(=[Se:13])[CH:3]([CH2:5][C:6]([O-:8])=[O:7])[OH:4].[C:2]([O-:10])(=[Se:13])[CH:3]([CH2:5][C:6]([O-:8])=[O:7])[OH:4].[Au+3:21]

Participants

6

Reactant 3

HCID 11430Potassium Carbonate2×HCID 86741669HCID 86741669, compoundHCID 131715218HCID 131715218, compound

Product 1

HCID 178477246HCID 178477246, compoundYield 180%

Reagents, catalysts & solvents 2

HCID 702EthanolCatalystHCID 6344DichloromethaneSolvent

Procedure

Then, 30 ml of an aqueous solution containing 3.2 g (10 mmol) of the above-obtained 2-selenoisourea malic acid hydrobromide was prepared. To the solution was dropwise added 20 ml of an aqueous potassium carbonate solution containing 2.04 g (22 mmol) of potassium carbonate at -10° C. To the thus obtained solution was dropwise added 3.51 g (10 mmol) of triethylphosphine gold chloride dissolved in ethanol containing a few drops of methylene chloride at -10° C., and then the mixture was stirred for 30 minutes while cooling, thereby to precipitate crystals. The crystals were filtered off and washed with water-ethanol, 0.1 N HCl and water, successively, thereby to obtain 3 g (6 mmol) of triethylphosphine gold selenomalate. The thus obtained triethylphosphine gold selenomalate was suspended in 20 ml of an aqueous solution containing 320 mg (3 mmol) of Na2CO3. The suspension was stirred for one hour and subjected to lyophilization. Thus, there was obtained 3 mmol of triethylphosphine gold sodium selenomalate.

Workup

  1. customwas prepared
  2. temperaturewhile cooling
  3. customto precipitate crystals
  4. filtrationThe crystals were filtered off
  5. washwashed with water-ethanol, 0.1 N HCl and water

Sources & evidence

ORD record
ord-353b1fc4cb4049068210a2e05b921720
Source dataset
uspto-grants-1987_07
Patent number
US04680286

Reaction notes

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