Ethyl chloroformate → 2-Ethoxycarbonylaminoindan-2-carboxylic Acid

Participants

Reaction Steps

To a stirred refluxing mixture of 2-aminoindan-2-carboxylic acid (1.90 g, 10.7 mmol, Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; and Howells, O. J. J. Med. Chem. 1971, 14, 892) in ethyl acetate (200 ml) ws added ethyl chloroformate (1.16 g, 10.7 mmol). After 15 hours, the mixture was cooled, filtered, evaporated, and vacuum dried to give 1.17 g (44%) of a white solid.

Provenance & Evidence