Ethyl chloroformate → HCID 14012618, compound

HRID 2118641Notes

Reaction equation

HRID 2118641 reaction equation
[NH2:1][C:2]1([C:11]([OH:13])=[O:12])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.Cl[C:15]([O:17][CH2:18][CH3:19])=[O:16]>C(OCC)(=O)C>[CH2:18]([O:17][C:15]([NH:1][C:2]1([C:11]([OH:13])=[O:12])[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10]1)=[O:16])[CH3:19]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 2509362-Aminoindane-2-carboxylic acid

Product 1

HCID 14012618HCID 14012618, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a stirred refluxing mixture of 2-aminoindan-2-carboxylic acid (1.90 g, 10.7 mmol, Pinder, R. M.; Butcher, B. H.; Buxton, D. A.; and Howells, O. J. J. Med. Chem. 1971, 14, 892) in ethyl acetate (200 ml) ws added ethyl chloroformate (1.16 g, 10.7 mmol). After 15 hours, the mixture was cooled, filtered, evaporated, and vacuum dried to give 1.17 g (44%) of a white solid.

Workup

  1. temperatureTo a stirred refluxing
  2. temperaturethe mixture was cooled
  3. filtrationfiltered
  4. customevaporated
  5. customvacuum dried

Sources & evidence

ORD record
ord-d5aa05f4e7da41ff90b063ebfd150ba1
Source dataset
uspto-grants-1987_07
Patent number
US04680284

Reaction notes

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