HCID 14012618, compound → HCID 88121557, compound

HRID 2118642Notes

Reaction equation

HRID 2118642 reaction equation
C([O:3][C:4]([NH:6][C:7]1([C:16]([OH:18])=[O:17])[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8]1)=[O:5])C>S(Cl)(Cl)=O>[C:4]([NH:6][C:7]1([C:16]([O:18][C:16]([C:7]2([NH:6][C:4]([OH:5])=[O:3])[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8]2)=[O:17])=[O:17])[CH2:8][C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:15]1)([OH:3])=[O:5]

Participants

3

Reactant 1

HCID 14012618HCID 14012618, compound

Product 1

HCID 88121557HCID 88121557, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

The resultant compound of Example 4 (500 mg, 2.00 mmol) was dissolved in thionyl chloride (3 ml). Evaporation after 17 hours provided a solid which was recrystallized from ethyl acetate/hexane to give 239 mg (59%) of the desired product.

Workup

  1. customEvaporation after 17 hours
  2. customprovided a solid which
  3. customwas recrystallized from ethyl acetate/hexane

Sources & evidence

ORD record
ord-6a98af2d20c04fdf8983bb17fcd42712
Source dataset
uspto-grants-1987_07
Patent number
US04680284

Reaction notes

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