Phosphoric Acid → HCID 178527088, compound

HRID 2118671Notes

Reaction equation

HRID 2118671 reaction equation
[CH:1]1([NH:7][C:8]([N:10](C2CCCCC2)[CH2:11][CH2:12][O:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)=[NH:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[P:30](=[O:34])([OH:33])([OH:32])[OH:31].CCO[CH2:38][CH3:39]>C(O)C>[P:30]([OH:34])([OH:33])([OH:32])=[O:31].[CH:1]1([NH:7][C:8]([NH:10][CH2:11][CH2:12][O:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)=[N:9][CH:39]2[CH2:38][CH2:3][CH2:2][CH2:1][CH2:6]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 1004Phosphoric AcidHCID 3283Diethyl EtherHCID 178512002HCID 178512002, compound

Product 1

HCID 178527088HCID 178527088, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

10.0 g of 1,3-dicyclohexyl-3-[2-(2-naphthyloxy)ethyl]guanidine was dissolved in ethanol (100 ml) and 5.7 g 85% phosphoric acid in 100 ml ethanol was added to this solution. After 16 hours 1400 ml ether was added to the solution. The resulting precipitate was removed by filtration and dried under vacuum to afford the title compound (mp 132°-134°).

Workup

  1. customThe resulting precipitate was removed by filtration
  2. customdried under vacuum

Sources & evidence

ORD record
ord-59a4db1bd9994796a63cd869c037b863
Source dataset
uspto-grants-1987_07
Patent number
US04680300

Reaction notes

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