Sodium Iodide → HCID 13787363, compound

HRID 2118679Notes

Reaction equation

HRID 2118679 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([OH:14])[CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Br[CH2:22][CH2:23][N:24]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[NH:26][C:25]1=[O:33].C([O-])([O-])=O.[Na+].[Na+].[Na+].[I-]>C(C(C)=O)C(C)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([OH:14])[CH:8]1[CH2:13][CH2:12][N:11]([CH2:22][CH2:23][N:24]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[NH:26][C:25]2=[O:33])[CH2:10][CH2:9]1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 10340Sodium CarbonateHCID 136334481-(2-Bromoethyl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 13787362HCID 13787362, compound

Product 1

HCID 13787363HCID 13787363, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

2.5 g (10-2 mole) of 4-[(2-pyridinyl)(phenyl)hydroxymethyl]piperidine, 2.5 g (10-2 mole) of 1-(1-bromo-2-ethyl)-1,3-dihydro-2(2H)-benzimidazolone, 1.2 g of Na2CO3, one crystal of NaI and 75 ml of methyl isobutyl ketone are introduced into a round flask.

Sources & evidence

ORD record
ord-f0eadfdc01624aab807fbeb6d8e6df58
Source dataset
uspto-grants-1987_07
Patent number
US04680296

Reaction notes

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