反应详情

A solution of 171 g of N-t-butylthiocarbonyl-2,5-dichloro-4-nitroaniline, described in Example 1, and 605 ml of N-methylpiperazine in 1700 ml of dimethylsulphoxide is heated at 140° for 8 hours, cooled and poured into water. The solid is filtered, washed with water and cold isopropanol to yield 2-tert-butyl-5-[4-methylpiperazin-1-yl]-6-nitrobenzothiazole, melting at 132°-135°.

1. temperatureis heated at 140° for 8 hours
2. temperaturecooled
3. filtrationThe solid is filtered
4. washwashed with water and cold isopropanol