Water → 2-Tert-butyl-6-nitro-5-[4-phenylpiperazin-1-yl]benzothiazole

Participants

Reaction Steps

A mixture of 7 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole described in Example 5, in 8.2 g of N-phenylpiperazine is heated at 150°-160° for 12 hours, cooled and poured into water. The paste is extracted with methylene chloride, washed with 2N HCl, then with 10% NaOH and then with water. The organic layer is dried, the solvent evaporated and the solid crystallised from isopropyl alcohol to give 2-tert-butyl-6-nitro-5-[4-phenylpiperazin-1-yl]benzothiazole, melting at 152°-155°.

Provenance & Evidence