反应详情

A mixture of 7 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole described in Example 5, in 8.2 g of N-phenylpiperazine is heated at 150°-160° for 12 hours, cooled and poured into water. The paste is extracted with methylene chloride, washed with 2N HCl, then with 10% NaOH and then with water. The organic layer is dried, the solvent evaporated and the solid crystallised from isopropyl alcohol to give 2-tert-butyl-6-nitro-5-[4-phenylpiperazin-1-yl]benzothiazole, melting at 152°-155°.

1. temperatureis heated at 150°-160° for 12 hours
2. temperaturecooled
3. extractionThe paste is extracted with methylene chloride
4. washwashed with 2N HCl
5. customThe organic layer is dried
6. customthe solvent evaporated
7. customthe solid crystallised from isopropyl alcohol