2-Methylpiperidine → [2-(2-Methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone

HRID 2118813Notes

Reaction equation

HRID 2118813 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[CH3:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][NH:22]1.C(=O)([O-])[O-].[Ca+2]>C(O)C>[CH3:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][N:22]1[C:2]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5]

Participants

5

Reactant 3

HCID 79742-MethylpiperidineHCID 10112Calcium CarbonateHCID 875720(2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone

Product 1

HCID 15072474[2-(2-Methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanoneYield 40.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Proceeding as indicated in example 2, from 0.035 mole (10.4 g) of 2,4'-dichloro-5-nitro-benzophenone, 0.07 mole (7 cm3) of 2-methylpiperidine and 0.035 mole (5 g) of calcium carbonate in ethanol, 5.1 g (Yield: 40%) of the expected product are obtained after recrystallization in ethanol. M.P. 142° C.

Sources & evidence

ORD record
ord-e0c0303907b14973bc1c7c8f75d278a2
Source dataset
uspto-grants-1987_07
Patent number
US04680402

Reaction notes

Loading…