HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calcium Carbonate → [2-(4-Hydroxy-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calcium Carbonate | HCID 10112 | — |
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | (2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone | HCID 875720 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | [2-(4-Hydroxy-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone | HCID 15072472 | 70% |
Reaction Steps
Proceeding as indicated in example 2, with 0.0506 mole (15 g) of 2,4'-dichloro-5-nitro-benzophenone, 0.076 mole (10.5 g) of calcium carbonate and 0.076 mole (76.8 g) of 4-hydroxypiperidine, in 100 cm3 of ethanol, 12.7 g (Yield: 70%) of the expected product are obtained after re-crystallization in ethyl acetate. M.P. 142° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680402 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-3d7399edeaf34f09887fb95d2d5be699 |
| Source note | uspto-grants-1987_07 |