Calcium Carbonate → [2-(4-Hydroxy-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanone

HRID 2118816Notes

Reaction equation

HRID 2118816 reaction equation
Cl[C:2]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].C(=O)([O-])[O-].[Ca+2].[OH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>C(O)C>[OH:25][CH:26]1[CH2:31][CH2:30][N:29]([C:2]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=2[C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2)=[O:5])[CH2:28][CH2:27]1

Participants

5

Reactant 3

HCID 10112Calcium CarbonateHCID 79341Piperidin-4-olHCID 875720(2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone

Product 1

HCID 15072472[2-(4-Hydroxy-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)-methanoneYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Proceeding as indicated in example 2, with 0.0506 mole (15 g) of 2,4'-dichloro-5-nitro-benzophenone, 0.076 mole (10.5 g) of calcium carbonate and 0.076 mole (76.8 g) of 4-hydroxypiperidine, in 100 cm3 of ethanol, 12.7 g (Yield: 70%) of the expected product are obtained after re-crystallization in ethyl acetate. M.P. 142° C.

Sources & evidence

ORD record
ord-3d7399edeaf34f09887fb95d2d5be699
Source dataset
uspto-grants-1987_07
Patent number
US04680402

Reaction notes

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