HuagongsheHuagongshe Chemistry Print Report · For research reference only
Calcium Carbonate → [2-(4-Ethyl-4-methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Calcium Carbonate | HCID 10112 | — |
| Reactant | (2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone | HCID 875720 | — |
| Reactant | 4-Ethyl-4-methylpiperidine | HCID 17750882 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | [2-(4-Ethyl-4-methyl-1-piperidinyl)-5-nitrophenyl]-(4-chlorophenyl)methanone | HCID 20193532 | 57.4% |
Reaction Steps
Proceeding as indicated in example 2 with 0.0734 mole (21.7 g) of 2,4'-dichloro-5-nitro-benzophenone, 0.11 mole (18 g) of 4-ethyl4-methylpiperidine and 0.22 mole (30.4 g) of calcium carbonate in 100 cm3 of N,N-dimethyl acetamide, 16.3 g (Yield: 57%) of the expected product are obtained after re-crystallization in isopropyl ether. M.P.: 105° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680402 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-bb256a145e794c6b814662c1745aa4ac |
| Source note | uspto-grants-1987_07 |