反应详情

A mixture of 0.024 mole (0.96 g) of NaOH, 25 ml of water, 0.02 mole (5.92 g) of 2,4'-dichloro-5-nitro-benzophenone and of 0.022 mole (2.6 ml) of 4-methylpiperidine is heated to 80° C. for three and a half hours. After cooling the reaction medium to normal temperature the resulting precipitate is filtered, washed in water and dried giving 6.74 g (Yield: 94%) of the expected product. M.P.=138° C. (Ex. 25) The compounds listed hereunder are obtained by reacting, in the same conditions as above, the 2,4'-dichloro-5-nitro-benzophenone with other piperidine derivatives (2-methyl, 3-methyl, 3,5-dimethylpiperidine):

1. temperatureAfter cooling the reaction medium to normal temperature the resulting precipitate
2. filtrationis filtered
3. washwashed in water
4. customdried