Decanoyl chloride → HCID 18608963, compound

HRID 2118955Notes

Reaction equation

[C:1](Cl)(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[Si:13]([O:20][C@@H:21]1[CH2:26][C@H:25]2[C@H:27]3[C@H:36]([CH2:37][CH2:38][C@:23]2([CH3:24])[C@H:22]1[OH:40])[C:35]1[CH:34]=[CH:33][C:32]([OH:39])=[CH:31][C:30]=1[CH2:29][CH2:28]3)([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>>[Si:13]([O:20][C@@H:21]1[CH2:26][C@H:25]2[C@H:27]3[C@H:36]([CH2:37][CH2:38][C@:23]2([CH3:24])[C@H:22]1[O:40][C:1](=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[C:35]1[CH:34]=[CH:33][C:32]([O:39][C:1](=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])=[CH:31][C:30]=1[CH2:29][CH2:28]3)([C:16]([CH3:19])([CH3:17])[CH3:18])([CH3:15])[CH3:14]

Participants

Reactant 2

HCID 66982Decanoyl chloride

HCID 18608961HCID 18608961, compound

Product 1

HCID 18608963HCID 18608963, compound

Procedure

With decanoyl chloride, under the conditions described in Example 3(a), 750 mg of 16α-(tert-butyldimethylsilyloxy)-1,3,5(10)-estratriene-3,17β-diol yields 1.10 g of 16α-(tert-butyldimethylsilyloxy)-3,17β-didecanoyloxy-1,3,5(10)-estratriene.

Sources & evidence

ORD record: ord-4958195dc7da4237afcb8a899d29ac5c
Source dataset: uspto-grants-1987_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04681875

Reaction notes

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