Potassium Carbonate → HCID 20191701, compound

HRID 2119007Notes

Reaction equation

HRID 2119007 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.[C:21]([O-:24])([O-:23])=O.[K+].[K+].[CH3:27][O:28][C:29]1[C:37]([O:38][CH3:39])=[CH:36][CH:35]=[CH:34][C:30]=1[CH2:31][CH2:32]Cl>C(OCCCC)(=O)C>[C:7]([OH:28])(=[O:8])/[CH:13]=[CH:14]/[C:21]([OH:24])=[O:23].[CH3:27][O:28][C:29]1[C:37]([O:38][CH3:39])=[CH:36][CH:35]=[CH:34][C:30]=1[CH2:31][CH2:32][N:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12828588HCID 12828588, compoundHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine

Product 1

HCID 20191701HCID 20191701, compoundYield 182.3%

Reagents, catalysts & solvents 1

HCID 31272Butyl AcetateSolvent

Procedure

A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]-benzoxazepine (2.93 g, 0.011 mole), K2CO3 (10 g), KI (0.1 g) and 2,3-dimethoxyphenethyl chloride (2.45 g, 0.012 mole) in 100 ml of n-butyl acetate was heated at reflux for 50 hours. The mixture was then filtered and concentrated to give 5.5 g of an oil.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 50 hours
  3. filtrationThe mixture was then filtered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-91e983f88ef540cc8dbbbbcc9d93a62e
Source dataset
uspto-grants-1987_07
Patent number
US04681879

Reaction notes

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