Sodium Iodide → HCID 14444213, compound

HRID 2119038Notes

Reaction equation

HRID 2119038 reaction equation
[CH2:1]([C:3]1[C:4](=[O:41])[NH:5][C:6](=[O:40])[N:7]([CH:39]=1)[C@@H:8]1[O:38][C@H:16]([CH2:17][O:18][C:19]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C@@H:10](OS(C)(=O)=O)[CH2:9]1)[CH3:2].[I-:42].[Na+]>COCCOC>[I:42][C@@H:10]1[C@@H:16]([CH2:17][O:18][C:19]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:38][C@@H:8]([N:7]2[CH:39]=[C:3]([CH2:1][CH3:2])[C:4](=[O:41])[NH:5][C:6]2=[O:40])[CH2:9]1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 13923448HCID 13923448, compound

Product 1

HCID 14444213HCID 14444213, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 5-ethyl-3'-O-methanesulfonyl-5'-O-trityl-2'-deoxyuridine (3.2 g, 5.6 mmole) and sodium iodide (15.0 g, 100 mmole) in 1,2-dimethoxyethane is refluxed for 18 hr.

Workup

  1. temperatureis refluxed for 18 hr

Sources & evidence

ORD record
ord-82f3a9212e3d4074ad5068ab4ba870cb
Source dataset
uspto-grants-1987_07
Patent number
US04681933

Reaction notes

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