Bromine → 4-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one
Reaction equation
[CH3:1][C:2]1([CH3:14])[CH:5]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2)[CH2:4][C:3]1=[O:13].[Br:15]Br>C(Cl)(Cl)Cl>[CH3:1][C:2]1([CH3:14])[CH:5]([C:6]2[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=2)[CH:4]([Br:15])[C:3]1=[O:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
2.08 g (0.01 mol) of 2,2-dimethyl-3-(4-chlorophenyl)cyclobutanone are dissolved in 30 ml of chloroform, and a solution of 1.6 g of bromine in 5 ml of chloroform is added dropwise. After stirring for one hour at 20° C., the solvent is distilled off under waterpump vacuum. 2.6 g of crude 2,2-dimethyl-3-(4-chlorophenyl)-4-bromocyclobutanone are obtained as a residue which is employed further without further purification (compare: Example 1).
Workup
- distillationthe solvent is distilled off under waterpump vacuum
Sources & evidence
- ORD record
- ord-ba5eb40b33b04962a57082208a8dc68a
- Source dataset
- uspto-grants-1987_07
- Patent number
- US04681952
Reaction notes
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