HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2119059Generated: November 1, 2026
Bromine → 4-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one
https://huagongshe.com/reaction/2119059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl- | HCID 11789026 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one | HCID 13277172 | 90.4% |
Reaction Steps
2.08 g (0.01 mol) of 2,2-dimethyl-3-(4-chlorophenyl)cyclobutanone are dissolved in 30 ml of chloroform, and a solution of 1.6 g of bromine in 5 ml of chloroform is added dropwise. After stirring for one hour at 20° C., the solvent is distilled off under waterpump vacuum. 2.6 g of crude 2,2-dimethyl-3-(4-chlorophenyl)-4-bromocyclobutanone are obtained as a residue which is employed further without further purification (compare: Example 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04681952 |
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| Source dataset | uspto-grants-1987_07 |
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| ORD ID | ord-ba5eb40b33b04962a57082208a8dc68a |
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| Source note | uspto-grants-1987_07 |
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