HCID 20191014, compound → HCID 20191013, compound

HRID 2119127Notes

Reaction equation

HRID 2119127 reaction equation
[OH:1][CH:2]([CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[N:12]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]>CO.[Pd].[C]>[OH:1][CH:2]([CH2:9][CH2:10][N:11]1[CH:15]=[CH:14][C:13]([NH2:16])=[N:12]1)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 1

HCID 20191014HCID 20191014, compound

Product 1

HCID 20191013HCID 20191013, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

A solution of the above crude ethyl 3-hydroxy-5-(3-nitropyrazol-1-yl)valerate (2.41 g.) in MeOH (250 ml.) was hydrogenated over 5% w/w Pd/carbon (0.3 g.) at atmospheric pressure over 2 hours. Uptake was 650 ml. The catalyst was filtered off and the filtrate was evaporated in vacuo to give ethyl 3-hydroxy-5-(3-aminopyrazol-1-yl)valerate as an oil (1.47 g.).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-00114f9bf32b4659a7059ae08b98bb83
Source dataset
uspto-grants-1987_07
Patent number
US04683228

Reaction notes

Loading…