Pivaloyl chloride → 4-(4-Chlorobenzoyl)phenyl 2,2-dimethylpropanoate

HRID 2119174Notes

Reaction equation

HRID 2119174 reaction equation
[OH:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[C:17](Cl)(=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19]>N1C=CC=CC=1>[C:17]([O:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1)(=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 1235044-Hydroxy-4'-chlorobenzophenone

Product 1

HCID 140104074-(4-Chlorobenzoyl)phenyl 2,2-dimethylpropanoate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.16 g (0.01 mole) of 4-hydroxy-4'-chlorobenzophenone and 1.2 g (0.015 mole) of pivaloyl chloride in solution were warmed to 50° C. for 3 hrs in 60 mls of dry pyridine with a drying tube attached. The solvent was removed via rotary evaporator and H2O added. The product was filtered and recrystallized from ethanol; 2.3 g (73%) yield; M.P.~113°-114° C.

Workup

  1. customThe solvent was removed via rotary evaporator and H2O
  2. additionadded
  3. filtrationThe product was filtered
  4. customrecrystallized from ethanol
  5. custom2.3 g (73%) yield

Sources & evidence

ORD record
ord-b463123c675e41f0973e732260642e87
Source dataset
uspto-grants-1987_07
Patent number
US04683241

Reaction notes

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