Pyridine → HCID 14010404, compound

HRID 2119176Notes

Reaction equation

HRID 2119176 reaction equation
[CH:1]1[CH:6]=[CH:5][C:4]([C:7]([C:9]2[C:14]([OH:15])=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1.N1C=CC=CC=1.[C:22](Cl)(=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24].C([O-])([O-])=O.[Na+].[Na+]>O>[C:22]([O:15][C:14]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:7]([C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)=[O:8])(=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24]

Participants

6

Reactant 4

HCID 1049PyridineHCID 83482'-HydroxybenzophenoneHCID 10340Sodium CarbonateHCID 62493Pivaloyl chloride

Product 1

HCID 14010404HCID 14010404, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 g. (0.005 mole) of O-hydroxybenzophenone was warmed in 25 mls of dry pyridine containing 1 g (0.01 mole) of pivaloyl chloride for 3 hrs. at 50° C. Poured into H2O containing 2 g of Na2CO3 and extracted with EtOAc+Et2O and washed with H2O. After drying over Na2SO4 and filtration, the product was isolated by evaporation of the solvent. Oily material. 1.2 g. (85%) yield.

Workup

  1. customat 50° C
  2. extractionextracted with EtOAc+Et2O
  3. washwashed with H2O
  4. dry with materialAfter drying over Na2SO4 and filtration
  5. customthe product was isolated by evaporation of the solvent
  6. custom(85%) yield

Sources & evidence

ORD record
ord-676a8f024a8d4ddfa68a1c26437c4637
Source dataset
uspto-grants-1987_07
Patent number
US04683241

Reaction notes

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