1-Methylimidazole → HCID 70387076, compound

HRID 2119222Notes

Reaction equation

HRID 2119222 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=1[CH3:12])=[O:4].[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>C(OCC)C>[Br-:1].[CH3:13][NH+:14]1[CH:18]=[CH:17][N:16]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=2[CH3:12])=[O:4])[CH2:15]1

Participants

4

Reactant 2

HCID 13901-MethylimidazoleHCID 20634502-Bromo-1-(2,4-dimethylphenyl)ethanone

Product 1

HCID 70387076HCID 70387076, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 4.76 g (0.021 mol) of 1-bromo-2-(2,4-dimethylphenyl)-2-oxoethane and 1.76 g (0.021 mol) of 1-methylimidazole in 50 ml of diethyl ether was stirred at room temperature for approximately 21 hours. The reaction solvent was decanted and the residue was washed with diethyl ether. The residue was recrystallized from acetonitrile/ethyl acetate to afford 3.32 g of the title product as white crystals. (51% yield) mp=179°-181° C.

Workup

  1. customThe reaction solvent was decanted
  2. washthe residue was washed with diethyl ether
  3. customThe residue was recrystallized from acetonitrile/ethyl acetate

Sources & evidence

ORD record
ord-de65f7ca93cf426faa8057562c722a00
Source dataset
uspto-grants-1987_07
Patent number
US04683312

Reaction notes

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