反应详情

Trifluoroacetylbenzotriazole in an amount of 4.0 g (18.6 mmol) was dissolved in 50 ml of THF, 2.3 g (10.9 mmol) of 4-(4-ethylcyclohexyl)cyclohexanol was added thereto, they were subjected to a reflux for 1 hour, and then the solvent was distilled off. After the residue was purified by column chromatography on silica gel (eluent: heptane/ethyl acetate=8/1), the solvent was distilled off, and the residue was subjected twice to recrystallization by using heptane to give 1.8 g (5.9 mmol) of trifluoroacetic acid 4-(4-ethylcyclohexyl)cyclohexyl ester. Yield of this compound based on 4-(4-ethylcyclohexyl)cyclohexanol was 54%.

1. temperaturea reflux for 1 hour
2. distillationthe solvent was distilled off
3. customAfter the residue was purified by column chromatography on silica gel (eluent: heptane/ethyl acetate=8/1)
4. distillationthe solvent was distilled off
5. customthe residue was subjected twice to recrystallization