反应详情

Trifluoroacetylbenzotriazole described above in an amount of 4.0 g (18.6 mmol) was dissolved in 50 ml of THF, 2.5 g (8.3 mmol) of 4-(4-(4-hydroxycyclohexyl)cyclohexyl)-1-propylbenzene was added thereto, they were refluxed for 1 hour, and then the solvent was distilled off. After the residue was purified by column chromatography on silica gel (eluent: heptane/ethyl acetate=3/1), the solvent was distilled off. The residue was subjected twice to recrystallization by using mixed solvent of heptane/ethyl acetate (1/5) to give 1.2 g (3.0 mmol) of trifluoroacetic acid 4-(4-(4-propylphenyl)cyclohexyl)cyclohexyl ester. Yield of this compound was 36%.

1. temperaturethey were refluxed for 1 hour
2. distillationthe solvent was distilled off
3. customAfter the residue was purified by column chromatography on silica gel (eluent: heptane/ethyl acetate=3/1)
4. distillationthe solvent was distilled off
5. customThe residue was subjected twice to recrystallization
6. additionby using mixed solvent of heptane/ethyl acetate (1/5)