反应详情

Trifluoroacetylbenzotriazole in an amount of 7.5 g (35 mmol) was dissolved in 75 ml of THF, 4.6 g (19 mmol) of 4-(4-butyl-cyclohexyl)cyclohexanol was added thereto, they were refluxed for 1 hour, and then the solvent was distilled off. After the residue was purified by column chromatography on silica gel (eluent: heptane/ethyl acetate=5/1), the solvent was distilled off, the residue was subjected twice to recrystallization by using heptane to give 1.5 g (4.5 mmol) of trifluoroacetic acid 4-(4-butylcyclohexyl)cyclohexyl ester. Yield of this compound based on 4-(4-butylcyclohexyl)cyclohexanol was 24%.

1. temperaturethey were refluxed for 1 hour
2. distillationthe solvent was distilled off
3. customAfter the residue was purified by column chromatography on silica gel (eluent: heptane/ethyl acetate=5/1)
4. distillationthe solvent was distilled off
5. customthe residue was subjected twice to recrystallization