HCID 69902277, compound → HCID 12971812, compound

HRID 2119294Notes

Reaction equation

Cl.[C:2]([O:6][C:7]([C@@H:9]1[NH:14][CH2:13][C:12]2[O:15][CH:16]=[CH:17][C:11]=2[CH2:10]1)=[O:8])([CH3:5])([CH3:4])[CH3:3].[N:18]1[CH:23]=[CH:22][C:21]([C:24]2[O:25][C:26]3[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][C:27]=3[CH:28]=2)=[CH:20][CH:19]=1>N1C=CC=CC=1>[C:2]([O:6][C:7]([C@@H:9]1[N:14]([S:33]([C:30]2[CH:31]=[CH:32][C:26]3[O:25][C:24]([C:21]4[CH:20]=[CH:19][N:18]=[CH:23][CH:22]=4)=[CH:28][C:27]=3[CH:29]=2)(=[O:34])=[O:35])[CH2:13][C:12]2[O:15][CH:16]=[CH:17][C:11]=2[CH2:10]1)=[O:8])([CH3:5])([CH3:3])[CH3:4]

Participants

Conditions

Temperature: 60 °C

Procedure

30 mmol of (5R)-4,5,6,7-tetrahydrofuro[2,3-c]pyridine-5-carboxylic acid tert-butyl ester hydrochloride are placed in 150 ml of pyridine. 30 mmol of 2-(4-pyridyl)-1-benzofuran-5-sulphonyl chloride described in Preparation C are then added at room temperature and the whole is heated at 60° C. overnight.

Workup

additionare then added at room temperature

Sources & evidence

ORD record: ord-7138e84762214165b2aab2371546f4c6
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686348B2

Reaction notes

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