Water → HCID 69901089, compound

HRID 2119295Notes

Reaction equation

HRID 2119295 reaction equation
[Si:1]([O:8][C:9]([CH:11]1[C:16]([CH3:18])([CH3:17])[S:15][CH2:14][CH2:13][NH:12]1)=[O:10])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:19][N:20]1CCOCC1.N1[CH:31]=[CH:30][C:29]([C:32]2[O:33][C:34]3[CH:40]=[CH:39][C:38]([S:41](Cl)(=[O:43])=[O:42])=[CH:37][C:35]=3[CH:36]=2)=[CH:28][CH:27]=1.O>ClCCl>[Si:1]([O:8][C:9]([CH:11]1[C:16]([CH3:18])([CH3:17])[S:15][CH2:14][CH2:13][N:12]1[S:41]([C:38]1[CH:39]=[CH:40][C:34]2[O:33][C:32]([C:29]3[CH:30]=[CH:31][C:19]([NH2:20])=[CH:27][CH:28]=3)=[CH:36][C:35]=2[CH:37]=1)(=[O:43])=[O:42])=[O:10])([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 79724-MethylmorpholineHCID 69899522HCID 69899522, compoundHCID 86585951HCID 86585951, compound

Product 1

HCID 69901089HCID 69901089, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

58.7 mmol of 2,2-dimethyl-3-thiomorpholinecarboxylic acid tert-butyl(dimethyl)silyl ester are dissolved in 500 ml of anhydrous dichloromethane. At −20° C., there are added 16 ml of N-methylmorpholine, followed by 57.5 mmol of 2-(4-pyridyl)-1-benzofuran-5-sulphonyl chloride described in Preparation C. The whole is stirred for 48 hours at room temperature and then poured into 300 ml of water. After decanting, washing with water, drying and evaporation, the expected product is obtained in the form of an oil.

Workup

  1. customdescribed in Preparation C
  2. customAfter decanting
  3. washwashing with water
  4. customdrying
  5. customevaporation

Sources & evidence

ORD record
ord-950c73afb61649798a62ae1297866d89
Source dataset
uspto-grants-2004_02
Patent number
US06686348B2

Reaction notes

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