反应详情

A mixture of N-benzylmethylamine (3.6 g, 30 mmol) and 4-(3-fluoro-4-nitrobenzyl)morpholine (2.4 g, 10 mmol) in acetonitrile (3.0 mL) is heated under reflux for 30 min and the solvent is then removed under reduced pressure. The residual oil is partitioned between ethyl acetate (70 mL) and sodium hydroxide solution (10 mL of 1 N) and the ethyl acetate phase is separated and washed twice with water (5 mL). The ethyl acetate is removed and the crude product is applied to a silica gel column. The column is eluted with 50% ethyl acetate/hexane to give 3.3 g of the title compound as an oil.

1. temperatureis heated
2. temperatureunder reflux for 30 min
3. customthe solvent is then removed under reduced pressure
4. customThe residual oil is partitioned between ethyl acetate (70 mL) and sodium hydroxide solution (10 mL of 1 N)
5. customthe ethyl acetate phase is separated
6. washwashed twice with water (5 mL)
7. customThe ethyl acetate is removed
8. washThe column is eluted with 50% ethyl acetate/hexane