Sodium Hydroxide → HCID 69892063, compound

HRID 2119337Notes

Reaction equation

HRID 2119337 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[C:22]([O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])=[C:21]([O:35][CH3:36])[C:20]([O:37][CH3:38])=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>C(O)C>[ClH:1].[ClH:1].[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([CH2:16][C:17]2[C:22]([O:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[C:21]([O:35][CH3:36])[C:20]([O:37][CH3:38])=[CH:19][CH:18]=2)[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23441327HCID 23441327, compound

Product 1

HCID 69892063HCID 69892063, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 g of the compound obtained in Example 1 are added to a solution containing 4 g of sodium hydroxide in 250 ml of ethanol. The whole is maintained for 6 hours without stirring. After removal of the solvent by evaporation, the residue is purified by chromatography over a silica column using a gradient of dichloromethane/methanol (95/5 to 0/100). The expected product is obtained in the form of the base and is converted to the corresponding dihydrochloride

Workup

  1. temperatureThe whole is maintained for 6 hours
  2. customAfter removal of the solvent
  3. customby evaporation
  4. customthe residue is purified by chromatography over a silica column

Sources & evidence

ORD record
ord-4d445413500043aa8bd6c32b0e3b2da6
Source dataset
uspto-grants-2004_02
Patent number
US06686360B2

Reaction notes

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