Sodium Hydroxide → HCID 69892063, compound

Participants

Reaction Steps

10 g of the compound obtained in Example 1 are added to a solution containing 4 g of sodium hydroxide in 250 ml of ethanol. The whole is maintained for 6 hours without stirring. After removal of the solvent by evaporation, the residue is purified by chromatography over a silica column using a gradient of dichloromethane/methanol (95/5 to 0/100). The expected product is obtained in the form of the base and is converted to the corresponding dihydrochloride

Provenance & Evidence