反应详情

温度

70 °C

A mixture of 120 mg of homopiperazine, 206 mg of homopiperazine dihydrochloride, and 3 mL of ethanol was heated to 70° C. to prepare a solution. 375 mg of sodium iodide and 287 mg of 3,3-diphenylpropyl methanesulfonate were added sequentially to the solution and the mixture was stirred at 70° C. for 14 hours. The mixture was allowed to cool to room temperature and the ethanol was removed under reduced pressure, followed by adding 20 mL of 2N aqueous sodium hydroxide solution and extracting with 20 mL×2 of ethyl acetate. The organic layers were combined, washed with 20 mL of saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered, and concentrated to give 1-(3,3-diphenylpropyl)homopiperazine.

1. customto prepare a solution
2. temperatureto cool to room temperature
3. customthe ethanol was removed under reduced pressure
4. additionby adding 20 mL of 2N aqueous sodium hydroxide solution
5. extractionextracting with 20 mL×2 of ethyl acetate
6. washwashed with 20 mL of saturated aqueous sodium chloride
7. dry with materialdried over anhydrous magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated