Lithium Hydroxide → HCID 12096141, compound

HRID 2119396Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([O:18]CC)=[O:17])=[N:7][C:6]=2[CH:21]=1.[OH-].[Li+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([OH:18])=[O:17])=[N:7][C:6]=2[CH:21]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 12096142HCID 12096142, compound

Product 1

HCID 12096141HCID 12096141, compound

Procedure

The title compound was prepared by a similar method to Preparation 3 from ethyl (2S)-1-(5-fluoro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate [see Preparation 19] and 1N aqueous lithium hydroxide to afford (2S)-1-(5-fluoro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid as a solid.

Sources & evidence

ORD record: ord-330a0581ac924fba81c330cf65a4b39e
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686357B1

Reaction notes

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