Lithium Hydroxide → HCID 53704113, compound

HRID 2119401Notes

Reaction equation

HRID 2119401 reaction equation
[F:1][C:2]([F:29])([F:28])[C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([N:11]3[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]3[C:17]([O:19]CC3C=CC=CC=3)=[O:18])=[N:8][C:7]=2[CH:27]=1.[OH-].[Li+]>>[F:28][C:2]([F:1])([F:29])[C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([N:11]3[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]3[C:17]([OH:19])=[O:18])=[N:8][C:7]=2[CH:27]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 54293075HCID 54293075, compound

Product 1

HCID 53704113HCID 53704113, compound

Procedure

The title compound was prepared by a similar method to Preparation 3 from benzyl (2S)-1-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]-2-piperidinecarboxylate [see Preparation 30] and 1N aqueous lithium hydroxide solution to afford (2S)-1-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]-2-piperidinecarboxylic acid as an oil.

Sources & evidence

ORD record
ord-43f0e6d7b42645b8a02497742072ee32
Source dataset
uspto-grants-2004_02
Patent number
US06686357B1

Reaction notes

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