1,3-Dichloro-2-isothiocyanatobenzene → HCID 22288834, compound

HRID 2119572Notes

Reaction equation

HRID 2119572 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]=S.[F:12][C:13]1[C:18]([F:19])=[CH:17][C:16]([NH2:20])=[C:15]([NH2:21])[CH:14]=1>C1COCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10]1[NH:20][C:16]2[CH:17]=[C:18]([F:19])[C:13]([F:12])=[CH:14][C:15]=2[N:21]=1

Participants

4

Reactant 2

HCID 1232391,3-Dichloro-2-isothiocyanatobenzeneHCID 27367551,2-Diamino-4,5-difluorobenzene

Product 1

HCID 22288834HCID 22288834, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

2,6-Dichlorophenyl isothiocyanate (0.3 g) and 4,5-difluoro-1,2-phenylenediamine (0.21 g) were stirred at RT for 4 h in THF (15 ml) and then concentrated and dried in a high vacuum. The foamy residue was dissolved in ethanol and heated to 70° C. with stirring. Methyl iodide (0.73 ml) was then added dropwise.

Workup

  1. concentrationconcentrated
  2. customdried in a high vacuum
  3. dissolutionThe foamy residue was dissolved in ethanol
  4. additionMethyl iodide (0.73 ml) was then added dropwise

Sources & evidence

ORD record
ord-9fe3cd48634b4d1882af70382d41cd97
Source dataset
uspto-grants-2004_02
Patent number
US06686384B2

Reaction notes

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