HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2119583Generated: October 26, 2026
Dimethylformamide dimethyl acetal → [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic Acid tert-butyl Ester
https://huagongshe.com/reaction/2119583
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | tert-Butyl 3-thioureidopropylcarbamate | HCID 20616909 | — |
| Product | [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic Acid tert-butyl Ester | HCID 72965844 | 90% |
Reaction Steps
A mixture of 1.48 g (6.35 mmol) (3-Thioureido-propyl)-carbamic acid tert-butyl ester and 15 ml Dimethylformamide dimethyl acetal was heated to 100° C. for 16 h. The mixture was concentrated and the residue was purified by flash column chromatography on silica eluting with ethyl acetate/n-hexane 1/1 to yield 1.65 g (90%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06686381B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-3f550b4ed4cc4b4e93e61486370bed76 |
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| Source note | uspto-grants-2004_02 |
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