2-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one → {3-[5-(2-Trifluoromethyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester

HRID 2119590Notes

Reaction equation

HRID 2119590 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([N:14]=[CH:15]N(C)C)=[S:13])([CH3:4])([CH3:3])[CH3:2].[F:20][C:21]([F:33])([F:32])[C:22]1[CH:31]=[CH:30][CH:29]=[CH:28][C:23]=1[C:24](=[O:27])[CH2:25]Br>>[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][C:25]([C:24](=[O:27])[C:23]2[CH:28]=[CH:29][CH:30]=[CH:31][C:22]=2[C:21]([F:20])([F:32])[F:33])=[CH:15][N:14]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 27784302-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-oneHCID 72965844[3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic Acid tert-butyl Ester

Product 1

HCID 20616907{3-[5-(2-Trifluoromethyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester

Procedure

The title compound was synthesised from [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic acid tert-butyl ester and 2-trifluoromethyl phenacylbromide (literature: EP 432040) according to the procedure described for Example 25. MS (m/e): 429.9 (MH+, 100%).

Sources & evidence

ORD record
ord-304e72f453c9466cba8b3378c30f9dd6
Source dataset
uspto-grants-2004_02
Patent number
US06686381B2

Reaction notes

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