HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one → {3-[5-(2-Trifluoromethyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one | HCID 2778430 | — |
| Reactant | [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic Acid tert-butyl Ester | HCID 72965844 | — |
| Product | {3-[5-(2-Trifluoromethyl-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester | HCID 20616907 | — |
Reaction Steps
The title compound was synthesised from [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic acid tert-butyl ester and 2-trifluoromethyl phenacylbromide (literature: EP 432040) according to the procedure described for Example 25. MS (m/e): 429.9 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06686381B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-304e72f453c9466cba8b3378c30f9dd6 |
| Source note | uspto-grants-2004_02 |