反应详情

To a solution of 290 mg (0.96 mmol) {5-[3-(1-Amino-ethylidene)-thioureido]-pentyl}-carbamic acid tert-butyl ester in 5 ml ethanol was added 213 mg (1 mmol) o-Methylphenacyl bromide and 139 μl NEt3 and allowed to stir for 5 h at room temperature. Afterwards the mixture was directly applied to preparative HPLC on reversed phase eluting with an acetonitrile/water gradient. The evaporation of the product fractions yielded 180 mg (45%) of the title compound.

1. washeluting with an acetonitrile/water gradient
2. customThe evaporation of the product fractions