2-Bromo-2'-methylacetophenone → HCID 20616910, compound

HRID 2119605Notes

Reaction equation

HRID 2119605 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]([N:15]=[CH:16]N(C)C)=[S:14])([CH3:4])([CH3:3])[CH3:2].[CH3:21][C:22]1[CH:31]=[CH:30][CH:29]=[CH:28][C:23]=1[C:24](=[O:27])[CH2:25]Br>>[C:1]([O:5][C:6](=[O:20])[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[S:14][C:25]([C:24](=[O:27])[C:23]2[CH:28]=[CH:29][CH:30]=[CH:31][C:22]=2[CH3:21])=[CH:16][N:15]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 124306762-Bromo-2'-methylacetophenoneHCID 72522555HCID 72522555, compound

Product 1

HCID 20616910HCID 20616910, compoundYield 69%

Procedure

The title compound was synthesised from [4-(3-Dimethylaminomethylene-thioureido)-butyl]-carbamic acid tert-butyl ester and 2-methyl phenacylbromide (Literature: WO9907666) according to the procedure described for Example 25 in 69% yield. MS (m/e): 390.2 (MH+, 100%).

Sources & evidence

ORD record
ord-ffcc58dd248442e29aa86aa6f7eeb431
Source dataset
uspto-grants-2004_02
Patent number
US06686381B2

Reaction notes

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