2-Thiophenesulfonyl chloride → HCID 20616891, compound

HRID 2119610Notes

Reaction equation

HRID 2119610 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][C:14]([C:18](=[O:27])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH2:25][CH3:26])=[C:15]([CH3:17])[N:16]=1)(C)(C)C.[S:29]1[CH:33]=[CH:32][CH:31]=[C:30]1[S:34](Cl)(=[O:36])=[O:35]>>[CH2:25]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:18]([C:14]1[S:13][C:12]([NH:11][CH2:10][CH2:9][CH2:8][NH:7][S:34]([C:30]2[S:29][CH:33]=[CH:32][CH:31]=2)(=[O:36])=[O:35])=[N:16][C:15]=1[CH3:17])=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 855182-Thiophenesulfonyl chlorideHCID 20616903HCID 20616903, compound

Product 1

HCID 20616891HCID 20616891, compound

Procedure

The title compound was prepared from {3-[5-(2-Ethyl-benzoyl)-4-methyl-thiazol-2-ylamino]-propyl}-carbamic acid tert-butyl ester and thiophene-2-sulfonyl chloride according to example BF. Off-white oil, 55%. MS (m/e): 448.1 (M+H, 100%).

Sources & evidence

ORD record
ord-6a3a9d8a2d244dc799f2d4b94424bff6
Source dataset
uspto-grants-2004_02
Patent number
US06686381B2

Reaction notes

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