反应详情

7-[4-(2-(Dimethylamino)ethoxy)benzyl]-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one was prepared according to the procedure of step 3 in EXAMPLE 11 using 7-[4-[2-(dimethylamino)ethoxy]benzyl]-9-chloro-1-methyl-1H-pyrazolo[4,3-b]-quinoline (Example 18, step 2), instead of 7-benzyl-9-chloro-1-methyl-1H-pyrazolo[4,3-b]quinoline. 7-[4-(2-(Dimethylamino)ethoxy)benzyl]-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (18 mg, 0.048 mmol) was treated with methanolic hydrochloric acid (5 ml) and the mixture was evaporated to give a yellow solid. The solid was recrystallized from 2-propanol and diethyl ether to afford 7 mg (27%) of the titled compound as a pale yellow solid.

1. customthe mixture was evaporated
2. customto give a yellow solid
3. customThe solid was recrystallized from 2-propanol and diethyl ether