Acetic Acid → HCID 23442326, compound

HRID 2119641Notes

Reaction equation

HRID 2119641 reaction equation
Cl[C:2]1[C:11]2[CH:10]=[C:9]([CH2:12][C:13]3[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=3)[C:16]#[N:17])[CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH:21]=[N:22][N:23]([CH3:24])[C:3]=12.C(O)(=[O:27])C>O>[CH3:24][N:23]1[C:3]2[C:2](=[O:27])[C:11]3[CH:10]=[C:9]([CH2:12][C:13]4[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=4)[C:16]#[N:17])[CH:8]=[CH:7][C:6]=3[NH:5][C:4]=2[CH:21]=[N:22]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 23442442HCID 23442442, compound

Product 1

HCID 23442326HCID 23442326, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A suspension of 3-[(9-chloro-1-methyl-1H-pyrazolo[4,3-b]quinolin-7-yl)methyl]benzonitrile (EXAMPLE 28, step 1, 729 mg, 2.19 mmol) in acetic acid (8 ml) and water (8 ml) was refluxed for 5 h. After cooling to room temperature, water (20 ml) was added and the precipitate was collected by filtration. This yellow solid was washed with water, ethanol and hexane to give 594 mg (86%) of the title compound as a yellow solid.

Workup

  1. temperaturewas refluxed for 5 h
  2. filtrationthe precipitate was collected by filtration
  3. washThis yellow solid was washed with water, ethanol and hexane

Sources & evidence

ORD record
ord-e4f591fe4b07429599ae3152f68bba8d
Source dataset
uspto-grants-2004_02
Patent number
US06686373B2

Reaction notes

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